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目的观察黄芪注射液对老年脑梗死恢复期胰岛素抵抗的影响。方法选择脑梗死恢复期患者 66例 ,按入院先后随机分为治疗组 3 3例 ,对照组 3 3例 ,两组均采用常规治疗 ,治疗组加用输液型黄芪注射液 ,疗程 2 0天 ,于治疗前后采取清晨空腹静脉血检测胰岛素 (Ins)、血糖 (FBS)、胆固醇 (CH)、甘油三酯 (TG)、空腹血清胰岛素 (FINS)以及血液流变学等 ,胰岛素抵抗用胰岛素敏感指数 (ISI)反映 ,并于治疗后进行相应的临床疗效评定。结果治疗组治疗后各项指标均有所降低 ,其中ISI明显降低 (P <0 0 1) ;同时CH、FBS、FINS以及血液流变学各异常指标均有改善 ,治疗前后及与对照组比较有显著性或高度显著性差异 (P <0 0 5或P <0 0 1) ;治疗组临床显效率亦明显优于对照组 (P <0 0 1)。结论黄芪注射液能明显降低老年脑梗死恢复期胰岛素抵抗、降低异常升高的血脂、血粘度 ,提高临床疗效等作用。
Objective To observe the effect of astragalus injection on insulin resistance in the recovery of senile cerebral infarction. Methods Sixty-six patients with convalescence of cerebral infarction were randomly divided into treatment group (n = 33) and control group (n = 33). The two groups were treated by conventional therapy. The treatment group received infusion of Astragalus injection for 20 days, Fasting venous blood samples were taken before and after treatment to detect Ins, FBS, TG, FINS, hemorheology, etc. Insulin resistance index (ISI) reflect, and after treatment, the corresponding clinical efficacy assessment. Results After treatment, the indexes of treatment group decreased, and the ISI was significantly decreased (P <0.01). At the same time, the abnormal indexes of CH, FBS, FINS and hemorheology were all improved, before and after treatment and compared with the control group There was significant or highly significant difference (P <0.05 or P <0.01). The clinical effective rate of the treatment group was also significantly better than that of the control group (P <0.01). Conclusion Astragalus injection can significantly reduce the recovery of elderly patients with cerebral infarction insulin resistance, reduce abnormally elevated blood lipids, blood viscosity, improve clinical efficacy and so on.