目的:评价伊来西胺(Ilepcimide)单药治疗儿童癫痫部分性发作的临床疗效及依从性。方法:收集2011年3～9月吉林大学第一医院小儿神经内科门诊癫痫部分性发作的患儿,2～5岁年幼组27例,5～15岁的年长组39例。所有患儿的伊来西胺初始计量均为5 mg·kg-1·d-1,如发作未被控制则每周加量<5 mg·kg-1·d-1,目标剂量为10 mg·kg-1·d-1,最大剂量<300 mg/d。观察期为6月,进行自身对照开放性研究,观察各组的维持期累计疗效,并进行安全性评估。结果:服药3个月后,年幼组的有效率、控制率分别为62.96%、40.74%,年长组的分别为64.10%、41.03%。服药6个月后,年幼组的有效率、控制率分别为77.78%、48.15%;年长组的分别为79.49%、51.28%。66例患儿在服药前及服药后第4周、3和6月时分别查血常规、尿常规、肝功能、肾功能、血液电解质及心电图,各项指标均未见异常改变。15.15%(10/66例)的患儿出现不良反应,主要表现为胃部不适、食欲差或恶心、疲倦、头晕、嗜睡的症状。结论:伊来西胺作为一种新型中药类抗癫痫药物对儿童癫痫部分性发作疗效良好,安全范围大,不良反应少,患者耐受性好,尤其适用伴有其他系统疾病的患者。 Objective: To evaluate the clinical efficacy and compliance of Ilepcimide monotherapy in the treatment of partial seizures in children. Methods: A total of 27 children aged 2 to 5 years old and 39 children aged 5 to 15 years old were enrolled in this study. The children with partial epilepsy in pediatric neurology outpatient department of Jilin University First Hospital from March to September of 2011 were collected. The initial dose of ililazine was 5 mg · kg-1 · d-1 in all children, and the weekly dose was less than 5 mg · kg-1 · d-1 if the attack was not controlled. The target dose was 10 mg · kg -1 · d-1, the maximum dose of <300 mg / d. The observation period was June. The self-control open study was conducted to observe the cumulative effect of each group during the maintenance period and to evaluate the safety. Results: After three months’ medication, the effective rate and control rate of young group were 62.96% and 40.74%, respectively, and those in the older group were 64.10% and 41.03% respectively. Six months after taking the medicine, the effective rate and control rate of the young group were 77.78% and 48.15% respectively, while those of the older group were 79.49% and 51.28% respectively. 66 cases of children before taking the medication and the first 4 weeks, 3 and 6 months were routine blood test, urine, liver function, renal function, blood electrolytes and ECG, the indicators were no abnormal changes. Adverse reactions were found in 15.15% (10/66 cases) of children with stomach discomfort, poor appetite or nausea, fatigue, dizziness and drowsiness. Conclusion: Yi Laxi amide as a new type of Chinese medicine antiepileptic drugs in children with partial epilepsy seizure good effect, wide range of safety, fewer adverse reactions, patients with good tolerance, especially for patients with other systemic diseases.