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目前对慢性肝病伴肝昏迷的治疗主要在于降低血氨、解除氨中毒和用左旋多巴取代脑组织中假性神经递质,使大脑恢复正常功能。但上述治疗不能改善病人的肝功能及解决肝性脑病病人的营养问题。1975年Fischer 等发现慢性肝功能不全或肝性脑病患者血浆氨基酸型式发生紊乱。他首次用特制的氨基酸混合液给实验性肝性脑病动物和病人输注,以纠正血浆氨基酸型式的异常状态,从而使动物和人
The current treatment of chronic liver disease with hepatic coma mainly lies in the reduction of blood ammonia, ammonia poisoning and the replacement of pseudo-neurotransmitter brain tissue with levodopa, so that the brain returned to normal function. However, these treatments can not improve the patient’s liver function and solve the nutritional problems of patients with hepatic encephalopathy. In 1975, Fischer found that patients with chronic hepatic insufficiency or hepatic encephalopathy had a disorder of plasma amino acid pattern. For the first time, he infused animals and patients with experimental hepatic encephalopathy with a specially formulated amino acid mixture to correct abnormalities in plasma amino acid patterns, thereby allowing animals and humans