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以 6名HBsAg、HBeAg均阳性的女性携带者及其子宫内感染HBV的 6例胎儿为对象 ,探讨母儿间病毒群的演变。检测母儿所携HBVS区 45 1～ 6 6 0、C区 2 0 2 2～ 2 30 1位核苷酸序列。结果表明了母儿间同源性 98%～1 0 0 % ,检出 5 30、5 46、5 81位点变异致使 1 2 6、1 31、1 43位氨基酸替代。 2对母儿C区同源性 1 0 0 % ,其中一对母儿均有原型株、变异株混合感染。结论子宫内感染大部分母亲将本身携带的优势毒株传给子代 ,从病毒株本身来看子宫内感染以变异株为多。HBV在母儿间传播中变异逐渐积累形成两代间所携病毒群的差异。
Six female fetuses with HBsAg and HBeAg positive and six fetuses infected with HBV in the uterus were used to investigate the evolution of the virus between mother and child. Detection of mother and child carrying HBVS 451 ~ 6 6 0, C area 202 202 ~ 2 30 1 nucleotide sequence. The results showed that the homology between maternal and child was 98% ~ 100%. A mutation at positions 5 30,5 46,5 81 was detected which resulted in amino acid substitutions of 126, 131, and 143. 2 pairs of mother C district homology 100%, of which a pair of mother and child have prototype strains, mutants mixed infection. Conclusion Most mothers with intrauterine infection pass the predominant strains they carry on their offspring. According to the strain itself, intrauterine infection is more mutated. The variation of HBV in mother-child transmission gradually accumulated and formed the difference between the two generations of the virus group.