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目的观察尼莫地平治疗脑血管疾病所致认知障碍的临床疗效。方法选取2013年1月—2016年1月常州市金坛区中医医院收治的脑血管疾病所致认知障碍患者420例,随机分为对照组和观察组,每组210例。对照组患者采用常规药物治疗,观察组患者在常规药物治疗基础上加用尼莫地平治疗;两组患者均连续治疗3个月。比较两组患者临床疗效、治疗前后简易精神状态量表(MMSE)评分及日常生活活动能力量表(ADL)评分、治疗期间不良反应发生情况。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前两组患者MMSE评分、ADL评分比较,差异无统计学意义(P>0.05);治疗后观察组患者MMSE评分高于对照组,ADL评分低于对照组(P<0.05);治疗后两组患者MMSE评分高于治疗前,观察组患者ADL评分低于治疗前(P<0.05)。观察组患者治疗期间不良反应发生率低于对照组(P<0.05)。结论尼莫地平治疗脑血管疾病所致认知障碍的临床疗效确切,可有效改善患者认知功能和日常生活活动能力,且安全性较高。
Objective To observe the clinical efficacy of nimodipine in the treatment of cognitive impairment caused by cerebrovascular diseases. Methods From January 2013 to January 2016, 420 patients with cognitive impairment caused by cerebrovascular diseases admitted to Jintan District Chinese Medicine Hospital of Changzhou were randomly divided into control group and observation group, with 210 cases in each group. The patients in the control group were treated with conventional drugs. The patients in the observation group were treated with nimodipine on the basis of conventional drug therapy. The patients in both groups were treated continuously for 3 months. The clinical efficacy, MMSE score, ADL score and adverse reactions during the treatment were compared between the two groups. Results The clinical efficacy of the observation group was better than that of the control group (P <0.05). There was no significant difference in MMSE score and ADL score between the two groups before treatment (P> 0.05). After treatment, MMSE score of observation group was higher than that of control group, ADL score was lower than that of control group (P <0.05) MMSE scores of patients in the group before treatment were higher than those in the observation group before treatment (P <0.05). The incidence of adverse reactions in observation group was lower than that in control group (P <0.05). Conclusion Nimodipine is effective in treating cognitive impairment caused by cerebrovascular diseases, which can effectively improve the cognitive function and activities of daily living in patients with high safety.