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目的:分析乳腺癌合并2型糖尿病患者的临床病理学特征,为合并2型糖尿病乳腺癌患者的早期预防及个体化治疗提供临床指导。方法:收集内蒙古医科大学附属医院腺体外科2011年1月至2014年1月收治的最初确诊为原发性乳腺癌患者,其中合并2型糖尿病的乳腺癌患者共52例,设为病例组。按照1∶2的原则随机选取同期就诊于内蒙古医科大学附属医院腺体外科的非糖尿病乳腺癌患者共104例,设为对照组。排除男性乳腺癌患者、1型糖尿病及继发性糖尿病患者。比较两组临床病理学特征。结果:(1)原发性乳腺癌患者年龄24~86岁,平均51岁。其中共52例(4.9%)患有2型糖尿病,平均年龄(58.9±12.02)岁。(2)与对照组比较,病例组体质量指数较大(P<0.05)、临床分期较晚(P=0.001)、病理T分期较晚(P=0.007)、腋窝淋巴结转移率较高(P=0.036)。两组年龄,肿瘤的位置,恶性肿瘤家族史,糖尿病相关性疾病,绝经状况,组织学分级,组织学类型,ER、PR、Her-2、Ki67的表达差异均无统计学意义(P>0.05)。结论:(1)合并2型糖尿病乳腺癌患者体质量指数较高、临床分期及病理T分期较晚、腋窝淋巴结转移率较高。(2)糖尿病可能是乳腺癌发生发展和淋巴结转移的危险因素。
Objective: To analyze the clinicopathological features of breast cancer patients with type 2 diabetes mellitus, and to provide clinical guidance for early prevention and individualized treatment of patients with type 2 diabetes mellitus. Methods: A total of 52 breast cancer patients with type 2 diabetes mellitus were enrolled from January 2011 to January 2014 in Department of Gynecologic Surgery, Affiliated Hospital of Inner Mongolia Medical University. The patients were initially diagnosed as primary breast cancer. According to the principle of 1: 2, 104 patients with non-diabetic breast cancer who were admitted to Department of Gynecology and Surgery, the Affiliated Hospital of Inner Mongolia Medical University were enrolled as the control group randomly. Exclude male breast cancer patients, type 1 diabetes and secondary diabetes. The clinical and pathological features of the two groups were compared. Results: (1) Patients with primary breast cancer aged 24 to 86 years, mean 51 years. Of these, 52 (4.9%) had type 2 diabetes mellitus, with an average age of 58.9 ± 12.02 years. (2) Compared with the control group, the body mass index (P <0.05), clinical stage (P = 0.001), pathological T stage later (P = 0.007) and higher axillary lymph node metastasis = 0.036). There were no significant differences in age, tumor location, family history of malignancy, diabetes related diseases, menopausal status, histological grade, histological type, ER, PR, Her-2 and Ki67 ). Conclusion: (1) Patients with type 2 diabetes mellitus have higher body mass index, late clinical stage and pathological T stage, and higher axillary lymph node metastasis rate. (2) Diabetes may be a risk factor for the development of breast cancer and lymph node metastasis.