妊毒症是以高血压、水肿和蛋白尿为主的综合征,对其内分泌方面的改变已有许多研究,但皮质醇与妊毒症时的高血压、液体潴留有无关系尚不十分清楚,本文就妊毒症孕妇的皮质醇动态,特别是孕妇血液、脐动脉、脐静脉及羊水中的皮质醇动态进行了研究.一、妊毒症孕妇的皮质醇孕妇血皮质醇比非孕时高,妊娠头三个月高一倍,后三个月高达两倍,这是由于皮质醇分泌增多、代谢廓清率减少,雌激素增加使结合皮质类固醇增多,以及肾上腺皮质对促肾上腺皮质激素(ACTH)敏感性增强 Hemotoxicity is a syndrome mainly characterized by hypertension, edema and proteinuria. There have been many studies on its changes in endocrine. However, it is still not clear whether cortisol is associated with hypertension or fluid retention during pregnancy. In this paper, pregnant women with pregnancy-induced cortisol dynamics, especially pregnant women in the blood, umbilical artery, umbilical vein and amniotic fluid cortisol dynamics were studied.First, pregnancy-induced cortisol pregnant women, blood cortisol than non-pregnant High, doubled in the first trimester and doubled in the third trimester due to increased cortisol secretion, reduced clearance rate of metabolism, increased estrogen binding with increased corticosteroids, and adrenocorticotropic effects on adrenocorticotropic hormone ( ACTH) increased sensitivity