当人体细胞处在“升温”(>37℃)的条件下,它们即受到热休克或称热应激的影响。“热”作为一种外界物理诱导物,经细胞表面受体的介导,将信息传入核内,从而调节基因的特异性表达。已有研究表明,热休克能引起细胞内热不稳定的蛋白质解折叠,形成溶解的球状过渡态并再聚集,其结果造成热休克因子 HSF的活化以及热休克蛋白的合成。热休克与细胞周期和 When human cells are under “warming” (> 37 ° C), they are exposed to heat shock or heat stress. “Hot ” as an external physical inducer, mediated by the cell surface receptors, the information into the nucleus, thereby regulating gene-specific expression. Studies have shown that heat shock can cause intracellular heat-labile protein unfolding, forming a dissolved globular transition state and re-aggregation, resulting in the activation of the heat shock factor HSF and heat shock protein synthesis. Heat shock and cell cycle and