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肽酰基精氨酸脱亚胺酶4(peptidylarginine deiminase 4,PADI4)在细胞核内组蛋白瓜氨酸化和基因表达调控方面发挥重要作用。许多研究显示,PADI4在一些疾病如类风湿关节炎(rheumatoid arthritis,RA)、胃癌、乳腺癌、肺癌、食管癌、结直肠癌、胰腺癌、卵巢癌、甲状腺癌、前列腺癌和系统性红斑狼疮(systemic lupus erythematosus,SLE)的发病过程中有重要作用。PADI4逐渐成为这些疾病诊断、治疗及预防方面的研究热点。本文就PADI4与RA和
Peptidylarginine deiminase 4 (PADI4) plays an important role in the regulation of histone citrullination and gene expression in the nucleus. Numerous studies have shown that PADI4 is effective in the treatment of several diseases such as rheumatoid arthritis (RA), gastric cancer, breast cancer, lung cancer, esophageal cancer, colorectal cancer, pancreatic cancer, ovarian cancer, thyroid cancer, prostate cancer and systemic lupus erythematosus (systemic lupus erythematosus, SLE) plays an important role in the pathogenesis. PADI4 has gradually become a hot spot in the diagnosis, treatment and prevention of these diseases. In this paper, PADI4 and RA and