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肿瘤转移包括一系列复杂的过程,主要涉及肿瘤细胞由原发部位脱离开始,到肿瘤细胞在其它转移部位——比如骨骼,生长增殖的多个关键性步骤.“种子和土壤学说”预示骨微环境中表达许多因子,吸引多种肿瘤细胞的迁移以及促进肿瘤的增殖.通过肿瘤细胞与其所处生长环境中的双向和动态的作用,促进肿瘤在骨骼中的发展.因此,骨微环境中产生的因子对肿瘤骨转移具有重要意义.本综述以前列腺癌为例,总结了肿瘤转移的机理研究概况,特别强调了目前有关肿瘤细胞与骨微环境之间相互作用研究的重要性,并提出了未来的研究方向.
Tumor metastasis involves a series of complex processes, mainly involving the key steps in tumor cell detachment from the primary site to the tumor cells at other sites of metastasis, such as bone growth and proliferation. “Seed and soil theory” Many factors are expressed in the environment, which can induce the migration of many kinds of tumor cells and promote the proliferation of tumors, and promote the development of tumors in the bones through the bidirectional and dynamic action of tumor cells and the growth environment in which they are located. Of the factors of tumor bone metastasis is of great significance.This review of prostate cancer, for example, summarizes the mechanism of tumor metastasis overview, with particular emphasis on the current study on the interaction between tumor cells and the bone microenvironment, the importance of research and proposed Future research direction.