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继发于中耳慢性感染的脑脓肿常为需氯和专性厌氧菌的混合感染,过去治疗首选青霉素,但剂量虽大死亡率仍高,可能是由于对青霉素高度耐药的脆弱类杆菌常存在于这类脓肿的缘故。本文报道9例耳源性脑脓肿的细菌学检查及对灭滴灵治疗的反应。9例均经手术抽脓,7例脓腔内注入抗菌素。所有病例开始治疗时均采用灭滴灵口服或静注,每8小时400～600毫克以抗厌氧菌,同时每6小时用青霉素0.6克或氨苄青0.5克以及每8小时用庆大霉素80毫克以抗需氧菌,以后根据培养结果调整用药。
Brain abscess secondary to chronic infection of the middle ear is often a mixed infection of chlorine-requiring and obligate anaerobic bacteria. In the past, penicillin was the first choice of treatment but the high mortality rate was probably due to the high resistance to penicillin Often exist in such abscess reason. This article reports 9 cases of otogenic brain abscess bacteriological examination and response to metronidazole treatment. 9 cases were pus by surgery, 7 cases of abscess injection of antibiotics. All cases were treated with metronidazole oral or intravenous infusion, 400-600 mg every 8 hours to anti-anaerobic bacteria, while every 6 hours with penicillin 0.6 g or 0.5 g of ampicillin and every 8 hours with gentamicin 80 mg Anti-aerobic bacteria, later adjusted according to the results of training medication.