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对1983年以来莫桑比克三个地区恶性疟原虫氯喹抗性的体内、体外测定资料进行了分析。349例恶性疟患者中26例为外来无免疫力者,余为当地具半免疫力者。剔除孕妇、并发症者、混合感染者、无症状带虫而原虫血症在400/μl以下者、7天内(有症状者14天内)服过抗疟药者以及服药后6小时内发生呕吐者。磷酸氯喹按基质给药,剂量分别为D_0 10mg/kg、D_1 10mg/kg、D_2 5mg/kg(首剂给药当日为D_0,余类推)。受试者7天内每日血检,7天后每周血检1次至28天止(无症状带虫者
In vitro and in vivo assay data of chloroquine resistance of Plasmodium falciparum in three regions of Mozambique since 1983 were analyzed. Of the 349 cases of falciparum malaria, 26 were non-immunocompromised and some were semi-immune. Excluding pregnant women, complications, mixed infections, asymptomatic parasites and parasitemia in 400 / μl or less, anti-malaria drugs in 7 days (within 14 days of symptoms) and vomiting within 6 hours after taking the drug . Chloroquine phosphate was administered as a matrix at dosages of D 0 10 mg / kg, D 10 mg / kg, and D 2 5 mg / kg (D 0 on the first dose, and so forth). Subjects daily blood tests within 7 days, 7 days after the weekly blood tests from 1 to 28 days (asymptomatic insects