糖尿病肾病(DN)是糖尿病(DM)最常见和最严重的慢性并发症之一,其病理特点是肾基底膜增厚和以肾小球系膜区为主的细胞外基质(ECM)积聚,导致弥漫性或结节性肾小球硬化,出现蛋白尿、肾功能衰竭等,而基底膜和ECM由胶原、非胶原糖蛋白和蛋白多糖构成,在胶原成分中,最重要的是IV型胶 Diabetic nephropathy (DN) is one of the most common and serious chronic complications of diabetes mellitus (DM). Its pathological features are the thickening of the renal basement membrane and the accumulation of extracellular matrix (ECM), which is mainly mesangial area, Leading to diffuse or nodular glomerulosclerosis, proteinuria, renal failure, etc., while the basement membrane and ECM are composed of collagen, non-collagen glycoprotein and proteoglycan. Among the collagen components, the most important is type IV adhesive