A computer-assisted method is presented for simultaneous optimization of pH and ion con-centration selection for the optimal separation in reversed-phase HPLC.
Condensation of 3-amino-4-cyanopyrazole (1) with ethylacetoacetate, ethyl cyanoacetate,diethyl malonate and acetylacetone afforded pyrazolo[1,5-a]pyrimidine de
A new and efficient method for the synthesis of potential antiviral agents Carba-ACV (3)and Carba-DHPG (4) is described. The synthesis makes the use of N- acet