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我院完成的85例同种异体肾移植患者中14例出现过高血糖,其中5例长期依赖降糖药物;9例在急性排斥反应皮质激素冲击治疗时血糖明显升高,冲击治疗后血糖降至正常,但9例中5例糖耐量试验异常。与激素冲击治疗的36例肾病综合征组对照,糖尿病发病率与血糖升高的程度有显著差异。5例血糖持续升高的患者中4例血环孢素A(CsA)浓度升高,血胰岛素、C肽降低,提示肾移植术后高血糖的发生除与皮质激素有关外,与血CsA浓度有密切的关系。
In our hospital, 85 cases of allograft kidney transplantation in 14 patients had hyperglycemia, of which 5 cases of long-term dependence on hypoglycemic drugs; 9 cases of acute rejection reaction corticosteroid blood glucose was significantly increased after the impact of blood glucose To normal, but in 9 cases, 5 cases of abnormal glucose tolerance test. 36 cases of nephrotic syndrome with hormone shock treatment control group, the incidence of diabetes and the degree of elevated blood glucose were significantly different. In 5 patients with persistent hyperglycemia, 4 patients had higher CsA concentration, lower blood insulin and C-peptide, suggesting that the occurrence of hyperglycemia after kidney transplantation was related to corticosteroid, There is a close relationship.