血管紧张素转换酶(ACE)抑制剂已成为治疗各型原发性高血压、肾血管性高血压、充血性心衰的重要手段。卡托普利由于含有巯基,毒副作用较多。依那普利(enalapril)为不含巯基的第二代ACE抑制剂。本文综述其临床药理学特点。药动学依那普利口服吸收率为60%,不受进食影响。其原形作用相对较弱,经肝脏酯解成依那普利拉(enalaprilat),为一强力ACE抑制剂。体内其他部位的水解酶也能完成这一转换,但当肝功能正常时,不起重要作用。口 Angiotensin converting enzyme (ACE) inhibitors have become an important treatment for various types of essential hypertension, renovascular hypertension and congestive heart failure. Captopril because of containing sulfhydryl, toxic side effects. Enalapril is a secondary thiol-free ACE inhibitor. This article summarizes its clinical pharmacology characteristics. Pharmacokinetics Enalapril oral absorption rate of 60%, free from eating. Its prototypical role is relatively weak, the enalaprilat by the liver ester solution, as a powerful ACE inhibitor. Other parts of the body of the hydrolase can also complete this conversion, but when the liver function is normal, does not play an important role. mouth