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目的:了解在常规抗生素预防方案基础上加用亚胺培南-西司他丁对预防移植早期感染的作用。方法:观察亚胺培南-西司他丁预防组(观察组,12例)和常规抗生素预防组(对照组,12例)造血干细胞移植患儿移植的早期感染发生情况。结果:所有患儿首次感染均发生在中性粒细胞绝对计数超过0.5×109/L之前。移植后早期感染最常见为呼吸道感染和口腔炎、胃肠炎等。观察组发生首次感染的时间犤(9±5)日犦较对照组犤(5±2)日犦明显推迟;且观察组发生感染时外周血白细胞均数显著高于对照组(P<0.05)。结论:移植前在常规抗生素预防方案基础上加用亚胺培南-西司他丁可推迟移植后早期感染的发生时间,对移植早期感染的预防有一定的效果。
OBJECTIVE: To understand the effect of adding imipenem-cilastatin to prevent early infection after transplantation based on routine antibiotic prophylaxis. Methods: The incidence of early infection in transplanted hematopoietic stem cell transplantation was observed in imipenem-cilastatin preventive group (observation group, 12 cases) and routine antibiotic prophylaxis group (control group, 12 cases). RESULTS: The first infection in all children occurred before the absolute neutrophil count exceeded 0.5 × 109 / L. Early posttransplant infection is the most common respiratory tract infections and stomatitis, gastroenteritis and so on. The time of the first infection in observation group was significantly delayed than that in control group (5 ± 2 days), and the number of peripheral leukocytes in observation group was significantly higher than that in control group (P <0.05) . CONCLUSION: Addition of imipenem-cilastatin to conventional antibiotic prophylaxis before transplantation may delay the onset of early posttransplant infection and may have some effect on the prevention of early transplant infection.