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急性白血病过去一向认为是致命的恶性疾病,自发性的缓解是极为罕见的,即使发生,也很短促,不久仍要复发。自从1948年采用了对抗叶酸代谢的一类药物后,从此为急性白血病的化疗打开了新的篇章。最近几年来,新的抗白血病药物,不断发明,治疗方法不断改进,缓解率显著提高,缓解期明显延长,甚至有少数急性淋巴细胞性白血病获得长期缓解,其中部分病人事实上已经治愈者。如1970年英国 Burchenal 广泛复习了各国自1948年以后的文献后,报告有159个急淋白血病患者(其中128个儿童,31个成人),从诊断成立时
Acute leukemia has always been considered to be a fatal malignant disease. Spontaneous remission is extremely rare. Even if it happens, it is very short and it will soon recur. Since the adoption of a class of drugs that combated the metabolism of folic acid in 1948, a new chapter has been opened in the treatment of acute leukemia. In recent years, new anti-leukemia drugs have been continuously invented, treatment methods have been continuously improved, remission rates have been significantly improved, remission periods have been prolonged, and even a few acute lymphoblastic leukemias have long-term relief, and some of these patients have actually been cured. For example, in 1970, British Burchenal extensively reviewed the literature of countries after 1948, reported 159 acute leukemia patients (128 children, 31 adults), from the time of diagnosis.