目的研究益元通脉方对不稳定型心绞痛的疗效及对血清高敏C反应蛋白(hs-CRP)和白细胞介素-6(IL-6)的影响。方法 60例不稳定型心绞痛(阳虚夹寒证)患者分为治疗组(30例),对照组(30例)。两组均采用西医标准强化疗法(抗缺血:改善心肌血供、β受体阻滞剂、钙拮抗剂、ACEI;抗血小板聚集、抗凝、调脂等,予硝酸甘油、美托洛尔、硝苯地平缓释片、依那普利、阿司匹林、低分子肝素、阿托伐他汀等)。治疗组加用益元通脉方,1剂/d,疗程为4周。各组在治疗前后检测血清hs-CRP和IL-6水平。结果治疗组心绞痛中长效疗效总有效率为86.67%,明显优于对照组的70.0%(P<0.05);中医证候积分及炎性指标下降亦优于对照组。治疗后两组不稳定型心绞痛患者血清中hs-CRP和IL-6明显低于入院时(P<0.01),治疗后治疗组血清中hs-CRP和IL-6明显低于对照组(P<0.05),具有统计学意义。结论在西医标准强化疗法的基础上,联合应用益元通脉方能提高治疗不稳定型心绞痛(阳虚夹寒证)的疗效,有效降低不稳定型心绞痛患者中的炎症标志物hs-CRP、IL-6浓度,提示该方可能通过抗炎途径治疗不稳定型心绞痛。 Objective To investigate the effects of Yi Yu Tong Mai Recipe (YYYTTT) on unstable angina pectoris and its effect on serum hs-CRP and IL-6. Methods Sixty patients with unstable angina (yang deficiency and cold syndrome) were divided into treatment group (30 cases) and control group (30 cases). Western medicine standard intensive therapy (anti-ischemia: improving myocardial blood supply, beta blockers, calcium antagonists, ACEI; anti-platelet aggregation, anticoagulation, lipid-lowering, etc.) , Nifedipine extended release tablets, enalapril, aspirin, low molecular weight heparin, atorvastatin, etc.). Treatment group plus Yi Tong Tongmai, 1 / d, treatment for 4 weeks. The levels of hs-CRP and IL-6 in serum were detected before and after treatment in each group. Results The total effective rate of long-term curative effect of angina pectoris in treatment group was 86.67%, which was significantly better than that in control group (70.0%, P <0.05). The TCM syndrome scores and the decline of inflammatory index were also better than those in control group. Serum hs-CRP and IL-6 levels in patients with unstable angina pectoris after treatment were significantly lower than those at admission (P <0.01). After treatment, hs-CRP and IL-6 in serum of patients in treatment group were significantly lower than those in control group (P < 0.05), with statistical significance. Conclusion Based on the standard intensified therapy of Western medicine, the combination of Yiyuan Tongmai can improve the curative effect of treating unstable angina pectoris (Yang Xuxan cold syndrome) and effectively reduce the hs-CRP of inflammatory markers in patients with unstable angina pectoris, IL-6 concentration, suggesting that the party may be through anti-inflammatory treatment of unstable angina.