论文部分内容阅读
目的了解新生儿和新生儿母亲的肠道病毒71型(Enterovirus Type71,EV71)和柯萨奇病毒A组16型(Coxsackievirus Group AType16,CVAl6)中和抗体(Neutralizing Antibody,NA)水平。方法选取广西壮族自治区和江苏省的3个手足口病(Hand,Footand Mouth Disease;HFMD)高发县和3个低发县作为研究现场,在每个县选取一个HFMD高发乡和一个低发乡,每个乡选择10对新生儿及新生儿母亲,对所有调查对象采集静脉血,并对新生儿母亲进行问卷调查。结果母亲EV71和CVA16的NA阳性率和几何平均滴度(Geometric Mean Titer,GMT)分别为83.5%、33.1%和1∶26.61、1∶6.1l,新生儿EV7l和CVA16的NA阳性率和GMT分别为75.2%、35.5%和1∶22.05、1∶6.97,母婴EV71、CVA16的NA阳性率及GMT差异均无统计学意义(2EV71=2.52,P=0.1124;2CVA16=0.1650,P=0.6846;tEV7l=1.05,P=0.2953;tCVA16=1.30,P=0.1946)。EV71、CVA16的NA阳性率和GMT在HFMD高、低发县差异亦无统计学意义(2EV71=1.45,P=0.2288;2CVA16=1.28,P=0.2583;tEV7l=1.86,P=0.0643;tCVA16=0.2,P=0.8399)。母婴EV71和CVA16的NAGMT均存在相关性(rEV71=0.69,P<0.0001;rCVA16=0.4769,P<0.0001)。结论母亲EV71和CVA16的NA阳性率和GMT高,新生儿EV71和CVA16的NA相应也高,可为新生儿提供有效保护。
Objective To investigate the levels of Enterovirus Type 71 (EV71) and Coxsackievirus Group AType16 (CVAl6) Neutralizing Antibody (NA) in neonates and newborn mothers. Methods Three HFMD high incidence counties and three low incidence counties in Guangxi Zhuang Autonomous Region and Jiangsu Province were selected as research sites. One HFMD high incidence and one low incidence was selected in each county. Ten couples of newborns and new mothers were chosen for each township, venous blood was collected for all subjects and a questionnaire survey of mothers of newborns was conducted. Results The positive rate of NA and the geometric mean titer (GMT) of the mothers EV71 and CVA16 were 83.5%, 33.1% and 1:26.61 respectively, and the ratio of the positive rate of GMT to the neonatal EV71 and CVA16 (2EV71 = 2.52, P = 0.1124; 2CVA16 = 0.1650, P = 0.6846; tEV7l was 75.2%, 35.5% and 1:22.05,1:6.97, respectively. There was no significant difference in the positive rates of NA and GMT between the two groups = 1.05, P = 0.2953; tCVA16 = 1.30, P = 0.1946). The positive rate of NA and the GMT of EV71 and CVA16 in HFMD were not statistically significant (2EV71 = 1.45, P = 0.2288; 2CVA16 = 1.28, P = 0.2583; tEV7l = 1.86, P = 0.0643; , P = 0.8399). There was a correlation of NAGMT between maternal and infant EV71 and CVA16 (rEV71 = 0.69, P <0.0001; rCVA16 = 0.4769, P <0.0001). Conclusion The positive rates of NA and GMT in mothers EV71 and CVA16 are high, and the NA of neonatal EV71 and CVA16 are correspondingly high, which can provide effective protection for neonates.