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为研究饲养室空气环境对大鼠卡氏肺孢子虫肺炎( P C P)诱导率的影响,将雄性清洁级 S D 大鼠随机分成两组,分别置于普通级饲养室(普通空气组,N＝ 54)及清洁级垂直层流室(清洁空气组,N＝ 50),均每周2 次皮下注射醋酸可的松25M G/只,连续12 周,然后做肺组织印片及支气管肺泡灌洗液沉渣涂片, GIEM SA 染色后镜检,并做肺组织切片, GROCOTT GOM ORI银染后检测卡氏肺孢子虫( P C),确定 P C P诱导率.结果显示,清洁空气组 P C P诱导率为28％ (14/50),明显高于普通空气组(0％ ,0/54, P＜ 0.001).而普通空气组细菌性肺炎的发生率(89％ ,48/54)明显高于清洁空气组(62％ ,31/50, P＜ 0.01).提示饲养室空气环境可 P C P的诱导率.“,”Male Clean SD rats were divided into two groups,and raised in conventional facility (open air,group 1,n=54) or in a room utilizing laminar air flow with filtration (clean air,group 2,n=50).To induce immunosuppression the rats were given cortisone acetate (25mg×2/week,sc)for 12 weeks,then the lung impression smears and bronchoalveolar lavage fluid sediment smears stained with Giemsa stain and lung sections stained with Grocott-Gomori silver stain were prepared to find Pneumocystis carinii (PC) organism.Bact...