In order to verify and study the dynamic response law on the double-sided loess slope under the action of the waves generated by automobile traffic, we select a double-sided loess slope from the long section of Anzi Road as the research object. Both field investigations and on-site monitoring processes are conducted, for the purpose of providing robust basis for road protection in these conditions. In detail, vehicle-induced vibration signals are different according to different vehicle types, speeds, as well as positions, and thus are collected, respectively. Based on the statistical analysis of the signals, the vibration response law and frequency spectrum characteristics of the slope are summarized. The results show that:① The dynamic response of the double-sided loess slope increases as the vehicle load increases, and the strong vibration response area is located in the middle of the side slope; ② When the vehicle load is small, the vibration wave amplification effect is obvious. On the contrary, when the vehicle load is large, the vibration wave amplification effect is weakened; ③ The spectrum distribution of the X-direction wave is single-peak shape, and the dominant frequency is concentrated in 30-50 Hz; the frequency spectrum distribution of the Z-direction wave shows a multi-peak shape, and the dominant frequency is concentrated in 20-180 Hz; ④ The vibration wave propagates in the slope. The frequency change shows little correlation with the type, speed and position of the vehicle, and instead, it is mainly determined by the slope itself. This study reveals the dynamic response on doubled-sided loess slopes and provides both theoretical and practical significance for the road protection in such situations.