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目的分析2000 2013年玉林市急性弛缓性麻痹(AFP)病例病毒学监测情况,为维持无脊髓灰质炎(脊灰)提供依据。方法按照世界卫生组织要求对玉林市2000 2013年所有AFP病例进行病毒分离与鉴定并对其进行流行病学分析。结果在451例AFP病例标本中,分离出脊灰病毒(PV)13株,非脊灰肠道病毒(NPEV)39株,分离率分别为2.88%和8.65%;13例PV阳性标本进行型内鉴定,共检出1株疫苗变异脊灰病毒,其余均为疫苗相关脊灰病毒,其中Ⅱ型7例,未发现脊灰野病毒。PV与NPEV全年均可检出,PV分离率12月较高;全市除陆川县、兴业县外,均检出脊灰病毒阳性病例;各年龄组之间PV分离率以<1岁最高,其次为1~4岁和>4岁组,分别为11.90%、9.60%和4.27%。完成脊灰减毒口服活疫苗(OPV)3次以上全程免疫的AFP病例的PV分离率低于未完成全程免疫者。结论玉林市2000 2013年未发现脊灰野病毒,维持了无脊灰状态。在实现无脊灰目标后,仍应加强AFP病例的病毒学监测工作,以确保最终实现全球消灭脊灰的目标。
Objective To analyze the virological status of acute flaccid paralysis (AFP) cases in Yulin in 2000 and provide basis for maintaining poliomyelitis-free (polio). Methods According to the requirements of WHO, all AFP cases of Yulin City in 2000 were isolated and identified and epidemiologically analyzed. Results Among 451 cases of AFP, 13 strains of poliovirus (PV) and 39 strains of non-polio enterovirus (NPEV) were isolated and the isolation rates were 2.88% and 8.65% respectively. Thirteen PV-positive specimens were typed Identification, detected a vaccine mutated poliovirus, the rest are vaccine-associated poliovirus, of which type Ⅱ 7 cases, no polio virus was found. PV and NPEV could be detected all year round, and the PV separation rate was higher in December; except for Luchuan County and Xingye County, poliovirus positive cases were detected in the city; PV separation rate among all age groups was the highest in <1 year old, Followed by 1 to 4 years old and> 4 years old group, respectively, 11.90%, 9.60% and 4.27%. The rate of PV isolation in AFP cases that had been immunized three times or more with live-attenuated oral poliovirus (OPV) was lower than those with incomplete immunizations. Conclusion Yulin City 2000 No wild poliovirus was found in 2013, maintaining a polio-free status. Following the goal of polio-free development, virological monitoring of AFP cases should be strengthened to ensure the ultimate goal of global polio eradication.