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喉上皮异型性增生、原位癌(CIS)可进一步发展为浸润癌。但某些CIS在致癌因素去除后可自发逆转。因此,在临床上CIS的治疗方案分歧颇大,有必要寻求一种能预测CIS发展趋势的标志。病理组织学重复性差,很难评价其预后。细胞核DNA异常反映了肿瘤细胞群体遗传特性的不稳定性,与肿瘤预后密切相关,已作为评价实体瘤包括头颈癌的预后因素之一。增殖细胞核抗原(PCNA)是细胞核内合成DNA所需的非组
Laryngeal atypia hyperplasia, carcinoma in situ (CIS) can further develop into invasive carcinoma. However, some CIS spontaneous reversal of cancer after removal of factors. Therefore, the treatment of CIS in the clinical program quite different, it is necessary to seek a sign that can predict the development trend of CIS. Histopathological poor reproducibility, it is difficult to evaluate the prognosis. Nuclear DNA abnormalities reflect the instability of the genetic characteristics of the tumor cell population and are closely related to the prognosis of the tumor and have been used as one of the prognostic factors for evaluating solid tumor including head and neck cancer. Proliferating cell nuclear antigen (PCNA) is a non-group required for the synthesis of DNA in the nucleus