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50年代已知冠心病人的血浆极低密度脂蛋白(VLDL)和低密度脂蛋白(LDL)平均浓度比健康人高。同样也证明了冠心病人的血浆高密度脂蛋白(HDL)浓度偏低。但后一发现并未引起重视,人们仍然集中注意于VLDL及LDL在形成粥样硬化中的作用。直至1975年Miller等才提出粥样硬化的发展速度可能与血浆HDL胆固醇浓度呈负相关的学说。他们认为HDL能促进胆固醇从动脉壁中转移出来。由于影响HDL代谢的因素很多,只有对其他相关变量进行控制或采用多变量统计技术的研究才能找出HDL胆固醇浓度与冠心病直接相关的证据。某协作研究组观察了生活在美国五个地方的、年龄
In the 1950s, the average concentration of plasma very low density lipoprotein (VLDL) and low density lipoprotein (LDL) in patients with coronary heart disease was higher than that in healthy people. Also demonstrated that coronary heart disease in patients with low plasma concentrations of high-density lipoprotein (HDL). However, the latter discovery did not pay attention, people still focus on the VLDL and LDL in the formation of atherosclerotic role. It was not until 1975 that Miller et al. Proposed that the rate of progression of atherosclerosis may be negatively correlated with plasma HDL cholesterol concentrations. They think that HDL can promote the transfer of cholesterol from the artery wall. Because of the many factors that affect HDL metabolism, only studies that control other related variables or use multivariate statistical techniques to find evidence that HDL cholesterol concentrations are directly linked to coronary heart disease. A collaborative research group looked at the age of five living in the United States