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目的：观察缓释维拉帕米治疗左心室（左室）舒张功能障碍的疗效。方法：心脏左室舒张功能障碍病人３６例（男性２６例，女性１０例，年龄４４±ｓ１０ａ），采用缓释维拉帕米１２０～２４０ｍｇ，ｐｏ，ｑｄ，观察４～６ｗｋ。结果：临床主要表现呼吸困难、第四心音及左室顺应性得到改善，总有效率为７８％，未见明显血糖、血脂变化及其他副作用。结论：缓释维拉帕米用于治疗左室舒张功能障碍，作用平稳持久，服用方便，副作用小，可作为一线治疗药物。
Objective: To observe the effect of sustained-release verapamil on left ventricular (LV) diastolic dysfunction. Methods: Thirty-six patients (26 males and 10 females, mean age 44 ± s10a) with left ventricular diastolic dysfunction were treated with sustained-release verapamil 120 ~ 240 mg, po, qd for 4 ~ 6 weeks. Results: The main clinical manifestations of dyspnea, the fourth heart sound and left ventricular compliance improved with a total effective rate of 78%, no significant changes in blood glucose, blood lipids and other side effects. Conclusion: The sustained-release verapamil is effective in the treatment of left ventricular diastolic dysfunction with stable and long-lasting effects. It is easy to take and has fewer side effects. It can be used as first-line treatment.