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目的探讨腹膜透析患者新发代谢综合征(MS)的危险因素。方法回顾性分析了腹膜透析时间超过24个月,并且稳定透析3个月时无MS的95例非糖尿病患者资料,对可能影响新发生MS的危险因素进行总结。以是否新发MS为因变量,纳入高尿酸(UA)血症、甘油三酯(TG)、高密度脂蛋白(HDL)、空腹血糖(Glu)和体重指数(BMI)5个变量引入方程进行多因素logistic回归分析。结果 95例患者新发MS组42例,无MS组53例。高UA血症(OR=5.076)、高TG(OR=3.134)、低HDL(OR=0.002)、高Glu(OR=3.163)和高BMI(OR=1.493)均与新发MS密切相关(P<0.05)。结论腹膜透析患者MS发病率较一般人群高;高UA血症、高TG、低HDL、高Glu和高BMI为新发MS的独立危险因素。
Objective To investigate the risk factors of new metabolic syndrome (MS) in peritoneal dialysis patients. Methods A retrospective analysis of 95 non-diabetic patients without peritoneal dialysis for more than 24 months and stable dialysis at 3 months was conducted to summarize the risk factors that may affect new-onset MS. Five new variables were included in the equation: whether or not new MS was the predominant factor and included hyperuricemia (UA), triglyceride (TG), high density lipoprotein (HDL), fasting glucose (Glu) and body mass index (BMI) Multivariate logistic regression analysis. Results In 95 patients, 42 cases were newly diagnosed with MS and 53 cases without MS. Hyperinsulinemia (OR = 5.076), high TG (OR = 3.134), low HDL (OR = 0.002), high Glu (OR = 3.163) and high BMI <0.05). Conclusion The incidence of MS in peritoneal dialysis patients is higher than that in the general population. High UAmia, high TG, low HDL, high Glu and high BMI are the independent risk factors for newly diagnosed MS.