聚集素是近年新发现的凋亡抑制蛋白,它广泛表达于各种组织及体液中,并参与多种生理及病理过程,包括免疫调节、细胞黏附、脂质转运、组织重构、膜循环及细胞凋亡、细胞周期调节等。近年研究发现,聚集素选择性地表达于某些肿瘤组织而在正常成熟组织中低表达,对肿瘤发生、发展具有重要作用。因此,对聚集素的深入研究可为阐明人类肿瘤的发生机制及肿瘤的诊断、治疗提供一个新的方向。 It has been widely expressed in various tissues and body fluids and participates in many physiological and pathological processes including immunomodulation, cell adhesion, lipid transport, tissue remodeling, membrane circulation and Apoptosis, cell cycle regulation and so on. In recent years, studies have shown that aggrecan is selectively expressed in some tumor tissues and low in normal mature tissues, which plays an important role in tumorigenesis and development. Therefore, in-depth study of agglutinin can provide a new direction for elucidating the mechanism of human tumors and the diagnosis and treatment of tumors.