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报道25例老年人高血压,用硝苯碇降压治疗二年以上,应用超声心动图观察左心室肥厚(LVH)的逆转过程。结果表明:降压治疗后左室心肌重量(LVM)降低29.10%(从268g±62g降到190g±49g P<0.001),二年后LVH逆转率为68.2%;LVH逆转过程中,室间隔厚度的改变出现较早,后壁厚度和左室腔径缩小相对较缓慢,主动脉内径与左房径无显著改变。年龄是影响LVH逆转的重要因素之一。结果提示硝苯啶长期有效降压治疗能够使大部份老年人高血压者的LVH发生逆转。
Reported 25 cases of elderly hypertension, nifedipine treatment for more than two years, the application of echocardiography observed left ventricular hypertrophy (LVH) reversal process. The results showed that the LVM decreased 29.10% (from 268g ± 62g to 190g ± 49g P <0.001) after antihypertensive treatment, and the LVH reversal rate after two years was 68.2%. During LVH reversal, the interventricular septum thickness Of the changes appeared earlier, the thickness of the posterior wall and left ventricular cavity diameter is relatively slow, aortic diameter and left atrium diameter no significant change. Age is one of the important factors that affect the reversal of LVH. The results suggest that nifedipine long-term effective antihypertensive treatment can make the majority of elderly hypertensive LVH reversed.