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目的:观察中西医结合治疗狼疮性肾炎的临床疗效。方法:将80例重症狼疮性肾炎随机分成两组。治疗组40例运用中医辨证使用中药,配合西药激素及环磷酰胺治疗,观察6个月;对照组40例单用激素和环磷酰胺治疗,疗程同治疗组。结果:治疗组总有效率为92.2%,对照组总有效率为80%,治疗组复发率5%,对照组复发率15%,两组有显著性统计学差异(P<0.05)。治疗前后两组血肌酐、尿蛋白的改善具有显著性统计学差异(P<0.05),但治疗组治疗后血肌酐、尿蛋白的改善优于对照组(P<0.05)。结论:中西医结合治疗狼疮性肾炎疗效优于单纯西药治疗,复发率低于西药组,值得临床推广。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of lupus nephritis. Methods: 80 cases of severe lupus nephritis were randomly divided into two groups. In the treatment group, 40 cases were treated with traditional Chinese medicine using traditional Chinese medicine and Western medicine with hormones and cyclophosphamide for 6 months. In the control group, 40 cases were treated with hormone and cyclophosphamide alone. The course of treatment was the same as that of the treatment group. Results: The total effective rate was 92.2% in the treatment group, 80% in the control group, 5% in the treatment group and 15% in the control group. There was a significant difference between the two groups (P <0.05). Before and after treatment, serum creatinine and urinary protein in both groups had significant statistical difference (P <0.05), but the improvement of serum creatinine and urinary protein in the treatment group was better than that in the control group (P <0.05). Conclusion: The treatment of lupus nephritis with traditional Chinese and western medicine is superior to western medicine only, and the recurrence rate is lower than western medicine group, which is worthy of clinical promotion.