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近年来,扰生素新品种发展极快,但对其一些副作用尚未被重视.本文就抗生素引起的出、凝血障碍作一综述。一、影响依赖维生素K 的凝血因子自1966年Goldman 等,首先报道青霉素G 引起出血以来,有关抗生紊药物(青霉素类、头孢菌素类,氨基甙类及四环族类等)引起凝血功能异常或出血的报道日益增加。Kam—组病人中,注射氨苄青霉素后,5例患者均发生凝血酶原减少症,其中2例出血严重需输血,2例少量出血.维生素K 治疗后,凝血酶原时间恢复正常,出血停止.Hooper等报道37例使用头孢羟唑,平均剂量为160mg/Kg/d,其中3例发生消化道出血,这3例分别患胃溃疡、腹腔肿瘤和左结肠坏疸.用药前凝血酶原时
In recent years, the new breed of turkey has developed rapidly, but some of its side effects have not been taken seriously.In this paper, antibiotic-induced coagulation disorders are reviewed. First, the impact of vitamin K-dependent clotting factor since 1966 Goldman et al., First reported that penicillin G-induced bleeding since the antibiotics (penicillins, cephalosporins, aminoglycosides and tetracyclics, etc.) cause coagulation disorders Or bleeding reports have been increasing. Among the Kam-group patients, prothrombin reduction occurred in all 5 patients after injection of ampicillin, with 2 patients requiring severe blood transfusion and 2 patients having a small amount of bleeding.After vitamin K treatment, prothrombin time returned to normal and bleeding stopped. Hooper et al reported 37 cases of cefotaxime, the average dose of 160mg / Kg / d, of which 3 cases of gastrointestinal bleeding, the three cases were suffering from gastric ulcer, abdominal tumor and left colon jaundice.