以甲基β-D-半乳糖苷为底物,用二丁基二甲氧锡作锡络合剂,脂肪酸酰氯作酰化剂选择性地合成半乳糖苷脂肪酸酯。最佳反应条件为:n(甲基β-D-半乳糖苷)∶n(二丁基二甲氧锡)∶n(脂肪酸酰氯)=1∶1.1∶1.1,温度为25℃,甲基3-O-脂肪酸酰基-β-D-半乳糖苷收率可达70%左右。并应用该糖酯类化合物作细菌Staphylococcusaureus和Salmonella agona的抗菌性测试,结果表明月桂酸酯和豆蔻酸酯分别使S.aureus的数量从5.322lgCFU/mL(空白)下降到3.441和3.563 lgCFU/mL;使S.agona的数量从6.094(空白)下降到3.813和3.830lgCFU/mL。 Using β-D-galactoside as substrate, dibutyltin methoxide as tin complexing agent and fatty acid chloride as acylating agent, galactoside fatty acid ester was selectively synthesized. The optimal reaction conditions are as follows: n (methyl β-D-galactoside): n (dibutyldimethoxy tin): n (fatty acid chloride) = 1: 1.1: -O-fatty acid acyl-β-D-galactoside yield of up to about 70%. The antimicrobial activity of this sugar ester compound was evaluated as Staphylococcus aureus and Salmonella agona. The results showed that laurate and myristate decreased the number of S. aureus from 5.322lgCFU / mL (blank) to 3.441 and 3.563 lgCFU / mL, respectively ; Decreased the number of S.agona from 6.094 (blank) to 3.813 and 3.830 lg CFU / mL.