论文部分内容阅读
本文观察蝙蝠葛碱(Dau)对神经动作电位影响,并与奎尼丁、利多卡因及丁卡因进行比较。发现Dau降低蟾蜍坐骨神经动作电位振幅(APA)和零相最大上升速率(Vmax),且随浓度加大而增强。与典型Ⅰ类抗心律失常药奎尼丁的作用相似,但降低APA50％所需之浓度(EC_(50))比奎尼丁大16倍,表明Dau阻Na~+内流弱于奎尼丁。而Dau EC_(50)又比局麻药丁卡因大24倍,小利多卡因2倍。从阻Na~+内流作用来看,
This article observed the effects of dauricine on neuronal action potentials and compared with quinidine, lidocaine and tetracaine. Dau was found to reduce the amplitude of the action potential (APA) and the maximum phase velocity (Vmax) of the sciatic nerve in toads, and increased with increasing concentration. Similar to quinidine, a typical class I antiarrhythmic agent, the concentration required to reduce APA 50% (EC 50) was 16 times greater than that of quinidine, indicating that Na + influx of Dau is weaker than that of quinidine . The Dau EC_ (50) and local anesthetic tetracaine 24 times larger, small lidocaine 2 times. From the resistance Na ~ + inflow effect point of view,