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研究了ＩＬ－１ｒａ对ＡＡ大鼠腹腔Ｍφ诱生细胞因子的调节机制进行了初步探讨。结果表明ＩＬ－１ｒａ能阻断ＩＬ－１刺激的亚适剂量ＰＨＡ诱导的胸腺细胞增殖，ＩＬ－１ｒａ能显著抑制正常及ＡＡ大鼠腹腔ＭφＩＬ－１、６、８，ＴＮＦ的产生，呈剂量依赖关系。ＩＬ－１ｒａ能显著下调腹腔ＭφＩＬ－８ｍＲ－ＮＡ表达。提示ＩＬ－１ｒａ是一种良好的抗炎制剂。
The regulatory mechanism of IL-1ra on cytokine in peritoneal Mφ induced by AA in rats was studied. The results showed that IL-1ra could block the PHA-induced thymocyte proliferation induced by IL-1 in a suboptimal dose. IL-1ra significantly inhibited the production of MφIL-1, 6,8 and TNF in peritoneal cavity of AA rats in a dose-dependent manner relationship. IL-1ra significantly down-regulated the expression of MφIL-8mR-NA in the peritoneal cavity. Tip IL-1ra is a good anti-inflammatory agent.