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目的:探讨辛伐他汀对慢性阻塞性肺疾病(COPD)患者肺动脉高压的影响.方法:将156例确诊为COPD合并肺动脉高压的患者随机分为治疗组和对照组,对照组78例作常规治疗,治疗组78 例在常规治疗基础上加辛伐他汀治疗.结果:对照组与治疗组FEV1％预计值、动脉氧分压(PaO2 )、动脉血氧饱和度(SaO2 )与治疗前比较均有明显升高、心脏彩色超声测量肺动脉收缩压(SPAP)均明显下降(P＜0.05),治疗组与对照组比较差异除FEV1％预计值外亦均有统计学意义 (P＜0.05).结论:联用辛伐他汀与对照组比较,能明显提高肺动脉氧分压和动脉血氧饱和度,降低SPAP,对肺动脉高压治疗安全、有效,但比较FEV1％预计值无统计学意义,需更进一步的研究证明.“,”Abstratc OBJECTIVE: To discuss the effect of simvastation to pulmonary hypertension ( PH)in the patients with chronic ob-structive pulmonary.METHODS: 156 patients with PH were randomly divided into treatment group ( n=78) and control group ( n=78).Control group received conventional treatment.The treatment group accepted simvastatin on the basis of the conventional treat-ment.RESULTS: PaO 2 and SaO 2 were significantly increased before treatment in the two groups.The SPAP was significant lower (P＜0.05).There was statiscally signifcant between the two groups except FEV1％expected (P＜0.05).CONCLUSION: Simvasta-tion can significantly improve PaO2 and SaO2,and decrease SPAP.It is safe and effective in the treatment of pulmonary hypertension.