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A series of new O~6-BG derivatives (14-21,23-30)were synthesized as inactivators of O~6-Alkylguanine-DNA alkyltransferase (AGT),and their ability to inhibit AGT was preliminary evaluated by MTT with O~6-BG as the control.The result suggested compound 30 displayed a higher activity than O~6-BG.
A series of new O ~ 6-BG derivatives (14-21,23-30) were synthesized as inactivators of O ~ 6-Alkylguanine-DNA alkyltransferase (AGT), and their ability to inhibit AGT was evaluated by MTT with O ~ 6-BG as the control. The result suggested compound 30 displayed a higher activity than O ~ 6-BG.