目的探讨经口径路切除内中上型咽旁间隙肿瘤的临床可行性。方法回顾性分析经口径路切除的24例内中上型咽旁间隙肿瘤患者的临床资料,其中7例神经鞘瘤,4例神经纤维瘤,9例混合瘤,4例脂肪瘤。肿瘤大小4.0cm×3.0cm×3.0cm至11.0cm×9.1cm×8.5cm。结果24例咽旁间隙肿瘤均经口径路完整切除,所有患者均痊愈。术后随访8个月-4年,经临床检查及影像学检查均未见肿瘤残留及复发。结论经口径路切除内中上型咽旁间隙肿瘤手术损伤小,术后恢复快,是该类型肿瘤较为理想的手术径路。 Objective To investigate the clinical feasibility of trans-calvarial resection of mid-upper parapharyngeal space tumor. Methods The clinical data of 24 cases of patients with intra-and large-sized parapharyngeal space tumor resected by oral biopsy were retrospectively analyzed. Among them, 7 were schwannoma, 4 were neurofibromas, 9 were mixed tumors and 4 were lipomas. Tumor size 4.0 cm × 3.0 cm × 3.0 cm to 11.0 cm × 9.1 cm × 8.5 cm. Results All the 24 cases of parapharyngeal space tumors were completely resected by caliber and all patients recovered. All patients were followed up for 8 months to 4 years. Neither tumor nor recurrence was found after clinical examination and imaging examination. Conclusion Surgical removal of intra-parietal-parapharyngeal space tumors by oral calculus is less invasive and faster after operation, which is an ideal surgical approach for this type of tumor.