通过糖耐量试验、测定血清葡萄糖和胰岛素水平,前瞻性评价含甲地妊娠素复方口服避孕药使用三月后对正常妇女碳水化合物代谢的影响。 21例自愿者,平均年龄27.4±0.2岁,平均体重137.5±5.6磅,产后三月以上,期间未用避孕药,其病史及体检包括盆腔检查和阴道细胞学涂片无异常发现。受试前,测定糖耐量作为对照即高糖饮食3天,禁食10小时以上,测定空腹及服75g葡萄糖负荷0.5,1,2,3小时后血清葡萄糖和胰岛素水平。给与单相口服避孕药,每月服用21粒,每粒含75μg甲地妊娠素和30μg炔雌醇。定期随访。在第3个月服药周期的最后一周对受试者作重复糖耐 Through glucose tolerance test, the level of serum glucose and insulin was measured. The prospective evaluation of the effect of gestagens containing oral contraceptives on the carbohydrate metabolism of normal women after three months was prospectively evaluated. Twenty-one volunteers, with an average age of 27.4 ± 0.2 years and an average body weight of 137.5 ± 5.6 pounds, were given more than three months postpartum with no contraceptives. Their medical history and physical examination included pelvic examination and vaginal smear. Before the test, glucose tolerance was measured as a control, that is, a high-sugar diet for 3 days and fasting for more than 10 hours. Serum glucose and insulin levels were measured after fasting and serving 75 g glucose load for 0.5, 1, 2 and 3 hours. Give single-phase oral contraceptives, taking 21 capsules a month, each containing 75 μg germagestine and 30 μg ethinyl estradiol. Regular follow-up. Repeat glucose tolerance in the last week of the third month of the drug cycle