灭滴灵除了用于治疗滴虫病外,已广泛用于防治厌氧菌感染等。灭滴灵能通过血脑屏障,可导致神经系统毒性。灭滴灵可引起嗜睡、失眠、多梦、头晕、谵语及精神错乱等。亦可引起轻度远端感觉神经病变,周围神经炎伴难以忍受的触痛感。1例成人患者服用灭滴灵750毫克,每6小时1次,28天后出现精神错乱、定向障碍,表现为共济失调及语言含糊等弥漫性小脑症候群,双足及双手烧灼感,停药6天后脑病及小脑共济失调消失,停药6个月后外周神经异常感觉消失。Schippper等报告1例灭滴灵引起周围神经病变及继发性共济失调。国内报告灭滴灵可引起精神异常伴不可逆性双下肢无力。大剂量灭滴灵可发生癫痫,Fryeak等报告口服大剂量灭滴灵发 In addition to metronidazole for the treatment of trichomoniasis, has been widely used to control anaerobic infections. Metronidazole can cross the blood-brain barrier and cause nervous system toxicity. Metronidazole can cause drowsiness, insomnia, dreams, dizziness, braille and confusion and so on. Can also cause mild distal sensory neuropathy, peripheral neuritis with unbearable tenderness. One adult patient took metronidazole 750 mg once every 6 hours. After 28 days, she developed insanity and disorientation. She showed diffuse cerebellar symptoms such as ataxia and vague language, and sensations of burning feet and hands. Days after the encephalopathy and cerebellar ataxia disappeared, withdrawal 6 months after the peripheral nerve abnormalities disappeared. Schippper et al reported that 1 case of metronidazole caused peripheral neuropathy and secondary ataxia. Domestic reports of metronidazole can cause mental disorders with irreversibility of both lower extremities weakness. Large doses of metronidazole epilepsy can occur, Fryeak et al reported oral metronidazole dose