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报告1978年8月～1995年12月住院病人中因抗痨药物引起的暴发性肝衰竭9例,致病药物PZA+RFP 3例、PZA 3例、RFP 2例、INH 1例。用药至黄疸发生的时间最短5天,最长240天,黄疸发生后2～27天(平均8.6天)陷入肝昏迷,虽经抢救均在2～36天(平均9天)死亡。2例病死后进行了穿刺肝组织病理检查。本文结合文献对其发生机制及防治进行讨论。
Nine patients with fulminant hepatic failure caused by anti-tuberculosis drugs in hospitalized patients from August 1978 to December 1995 were reported. There were 3 pathogenic drugs PZA + RFP, 3 PZA, 2 RFP and 1 INH. Medication to jaundice occurred in the shortest 5 days, up to 240 days, 2 to 27 days after the onset of jaundice (average 8.6 days) into hepatic coma, although the rescue were in 2 to 36 days (average 9 days) died. Two cases died of liver biopsy after biopsy. This article combines the literature on its mechanism and prevention discussed.