[目的]分析目标导向液体与常规液体治疗对脑膜瘤切除术患者的疗效影响.[方法]选取本院收治的60 例脑膜切除术患者的临床资料,根据治疗方法不同分为对照组(采用常规液体治疗)和观察组(采用目标导向液体治疗),每组各 30 例,分析两组患者治疗后的临床效果,血氧饱和度(SaO2 、SjvO2 )、血氧分压(PaO2 、PjvO2 )及血清NSE、S1 00β、SOD、MDA水平.[结果]观察组患者手术时间、住院天数、监护病房停留时间短于对照组,差异有统计学意义(P 0.05).治疗后,观察组患者SOD水平高于对照组,NSE、S1 00β蛋白、MDA水平低于对照组,脑代谢指标优于对照组,差异有统计学意义(P <0.05).[结论]目标导向液体治疗对行脑膜瘤切除术患者术后康复以及脑代谢产生积极的影响,值得临床推广运用.“,”[Objective]To analyze the effect of target-oriented fluid and conventional fluid therapy on the efficacy and cognitive function of patients with meningioma resection[Methods]A total of 60 patients with meningioma resection were selected in our hospital from August 2015 to December 201 7.According to the different therapeutic methods,they were divided into the control group and the observation group.Patients in the control group were treated by conventional liquid treatment whilepatients in the observation group were treated by the target-oriented liquid treatment.Analysis of the clini-cal effect and indexes (SaO2 ,SjvO2 ,PaO2 ,PjvO2 ,NSE,S100β,SOD and MDA)of the two groups of patients after treatment was conducted.[Results]The operation related durations (operation time,hospitalization and ICU)of the ob-servation group were shorter than those of the control group (P 0.05).After treatment,the SOD level in patients of the observation group was higher than that of the control group,while NSE,S100β protein and MDA levels were lower than those of the control group,and cerebral metabolic index was better than that of control group;the differences were statistically significant (P<0.05).[Conclusion]Target-oriented liquid treatment has positive effect on postoperative rehabilitation and brain metab-olism in patients with meningioma resection .Thus,it is worthy of clinical promotion.