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作者曾发现肾病综合征病人尿激肽释放酶(UK)排出超过正常,部分病人伴有血浆肾素活性(PRA)升高。本文进一步研究肾病综合征患者 UK 和 PRA 的关系。病人和方法作者将16例肾病综合征按其 PRA分成高肾素(12.1±3.7ng/ml)和正常肾素(1.2±0.3ng)组,并以22名健康人(PRA1.45±0.22ng/ml)作为对照,测定 UK 并作比较。肾病综合征两组间除正常肾素组年龄(58.4±6.2岁)大于高肾素(33.8±5.3岁)组外,内生肌酐清除率、尿蚤白排泄量、血清白蛋白和尿钠排泄率均无差别。肾病综合征者在研究期间钠呈正平衡,体重增加。
The authors have found that patients with nephrotic syndrome, urinary kallikrein (UK) excreted more than normal, some patients with elevated plasma renin activity (PRA). This article further studies the relationship between UK and PRA in patients with nephrotic syndrome. Patients and Methods The authors divided 16 patients with nephrotic syndrome into two groups according to PRA: high PR (12.1 ± 3.7ng / ml) and normal PR (1.2 ± 0.3ng), and 22 healthy individuals (PRA 1.45 ± 0.22ng / ml) as a control, measured UK and compared. Nephrotic syndrome between the two groups in addition to the normal renin group (58.4 ± 6.2 years old) was higher than the high renin (33.8 ± 5.3 years) group, the endogenous creatinine clearance, urinary fleabane excretion, serum albumin and urinary sodium excretion Rate no difference. Nephrotic syndrome during the study showed a positive balance of sodium, weight gain.