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临床使用补肾中药骨痹丸治疗氟骨症效果满意。为了进一步探讨其疗效机理是否通过脱释骨氟入血,由尿排出而进行此实验,现将结果报告如下。1 材料与方法1.1 模型确定 选包头西部柏树沟严重氟污染区:牧草氟241.2mg/kg,大气氟8.6mg/m~3,土壤水溶氟表层7.6mg/kg,深层4.7mg/kg同种白山羊,年龄2.5岁,体重25kg,雌雄兼有。按自拟氟骨症模型标准确定,标准为1、出现氟斑牙;2、肋骨(手术取材)氟≥3000mgkg;3、
The clinical use of Bushen Chinese Guwei Pills was effective in treating skeletal fluorosis. In order to further investigate whether the therapeutic mechanism is through the release of bone fluoride into the blood, this experiment was performed by urine excretion. The results are reported below. 1 Materials and methods 1.1 Model identification Baotougou serious fluorosis in the western part of the baotou area: forage fluoride 241.2mg/kg, atmospheric fluoride 8.6mg/m~3, soil soluble fluorine surface layer 7.6mg/kg, deep layer 4.7mg/kg same white Goats, 2.5 years old, weighing 25 kg, both male and female. According to the standard model of skeletal fluorosis, the standard is 1, the occurrence of fluorosis; 2, ribs (surgery) fluorine ≥ 3000mgkg; 3,