2-氨基 - 4′-溴 -二苯甲酮 (1)是植物生长调节剂及园艺用杀菌剂异菸碱酰替苯氨的关键中间体[1] ,也是医药原料的重要中间体 ,可用于合成治疗眼科发炎类药物 [2 ] 。文献合成路线如下 :其中 ,以邻氨基苯甲酸为原料的路线 ,最后一步付 -克反应收率低 ,只有 2 8%;以对溴碘苯或对 2-Amino-4’-bromo-benzophenone (1) is a key intermediate for plant growth regulators and isonicotinamide for horticultural fungicides [1], and is also an important intermediate for pharmaceutical raw materials, which can be used In the synthesis of ophthalmic inflammatory drugs [2]. Literature synthesis route is as follows: Among them, the route of anthranilic acid as the raw material, the final step of the reaction rate of the reaction is low, only 28%; with bromo-iodo-benzene or