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目的探讨循证药学对临床抗生素合理应用的影响及作用。方法我院收治碳青霉烯类抗生素治疗的患者，随机的分为对照组和观察组，依据于循证药学原则，在万方、知网等数据库进行检索，总结治疗方案。结果观察组患者应用循证药学治疗明显优于对照组，其复发率以及肝功能损害发生率明显低于对照组，<0.05。结论依据于循证药学的方法使用抗生素治疗患者，避免了不合理的用药情况，并提高了临床抗生素用药的安全性。“,”Objective To explore the ef ect of evidence-based medicine on clinical rational use of antibiotics and the role. Methods Admit ed to our hospital for treatment of carbapenem antibiotics patients were randomly divided into control group and observation group,on the basis of the principle of evidence-based pharmacy,were retrieved in Wanfang,HowNet database,summary treatment scheme.Results The patients in the observation group application of evidence-based pharmacy treatment was bet er than the control group,the recur ence rate and the damage of liver function was significantly lower than the control group, <0.05.Conclusion The method was based on evidence based pharmacy using antibiotics in the treatment of patients,to avoid medication unreasonable,and improves the safety of clinical antibiotic drugs.