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目的:探讨应用前列腺素E1注射液治疗血栓闭塞性脉管炎的临床效果。方法:2001年3月～2008年3月间我院外科共收治43例血栓闭塞性脉管炎患者,按病情不同取前列腺素E1(PGE1)静脉滴注治疗,对其疗效进行观察及随访。结果:43例患者中,15例患者经过7～14天治疗,疼痛消失,感觉和皮肤正常,病变及远侧动脉搏动正常,无坏疽和溃疡。28例患者疼痛缓解,皮肤变浅,病变及远侧动脉搏动无明显减弱,坏疽和溃疡面缩小。时间最短者治疗7天显著好转,时间最长者为14天,有效率100%,静点中无副作用。讨论:前列腺素E1(PGE1)在本病中疗效确切,作用快,安全价廉,适合基层单位使用,有推广价值。
Objective: To investigate the clinical effect of prostaglandin E1 injection in the treatment of thromboangiitis obliterans. Methods: From March 2001 to March 2008, 43 cases of thromboangiitis obliterans were treated in our hospital. The patients were treated with intravenous infusion of prostaglandin E1 (PGE1) according to different disease conditions. The curative effect was observed and followed up. Results: Among the 43 patients, 15 patients were treated for 7 to 14 days, the pain disappeared, the sensation and skin were normal, the lesions and distal arteries were normal, and no gangrene and ulcers were found. 28 patients with pain relief, skin lightening, lesions and distal arterial pulse was not significantly reduced, gangrene and ulcers narrowed. The shortest treatment time was significantly improved 7 days, the longest time for 14 days, the efficiency of 100%, no side effects in the static point. Discussion: prostaglandin E1 (PGE1) in the disease curative effect is exact, quick, safe and inexpensive, suitable for use by grassroots units, with promotional value.