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硫喷妥钠可用硝酸汞滴定,用固态膜汞(Ⅱ)离子选择性电极作指示电极,在体系中加入乙醇可获清晰的滴定电位突跃,研究了实验变量的影响,研究了pH9.0～11.0范围的最佳实验条件,方法试用于硫喷妥钠针剂的分析。目前,药典多采用萃取——重量法和分光法测定硫喷妥钠的含量,均较繁琐。文献曾报导用银离子电极,AgNO_3作滴定剂,电位法测定其含量。惜Ag~+离子电极响应缓慢,且终点电位突跃较小,难获良好的结果,我们利用Hg~(2+)能与硫喷妥钠形成一定组成的不溶性缔合物的反应,以市售Hg~(2+)离子电极作指示,Hg(NO_3)_2作滴定剂,电位法测定硫喷妥钠针剂的含量,方法简便、快速,所得结果较前文方法更佳。
Thiopental could be titrated with mercury nitrate and solid-phase membrane mercury (Ⅱ) ion-selective electrode was used as the indicator electrode. Ethanol was added to the system to get a clear titration potential jump. The effects of experimental variables were studied. The effects of pH 9.0 ~ 11.0 range of the best experimental conditions, methods for the analysis of thiopental injection. At present, pharmacopoeia more by extraction - gravimetric and spectrophotometric determination of thiopental sodium content, are more cumbersome. Literature has reported the use of silver ion electrode, AgNO_3 titrant, potentiometric determination of its content. Unfortunately, the response of Ag ~ + ion electrode is slow, and the terminal potential jump is small, so it is hard to get good results. We use the reaction of Hg 2+ with insoluble adjuvant with a certain composition of thiopental, Hg 2+ ion electrode was used as an indicator, Hg (NO_3) _2 as a titrant and potentiometric method to determine the content of thiopental sodium injection. The method was simple and rapid and the results were better than the previous method.