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早自1966年在溶栓治疗中已有蛇毒制剂。Bell用马来西亚红口蝮蛇治疗几种血栓病,其中包括1例 急性心肌梗塞(AMI)。近年来我国用江浙(白眉、蛇岛)蝮蛇、尖吻蝮蛇蛇毒治疗AMI,效果较好。我学院蛇毒研究所管锦霞,余清声对广东等南方省份大量蕴藏的眼镜蛇的蛇毒进行了研究,发现这种蛇毒具有很好的抗凝、溶纤、解血小板聚集作用,其提取物定名为“抗血栓素”(Antithromboxin,ATX)。在经过一系列基础实验之后,我们用于治疗AMI17例,疗效满意。用最初制备的ATXⅠ治疗者8例,于1990年作过报道,此次连同用后来制备的ATXⅡ(提自蛇毒的抗凝、溶纤及解血小板聚集之组分)治疗者9例,一并加以总结。
As early as 1966 in thrombolytic therapy has snake venom preparations. Bell treated several thrombus diseases with the Malaysian Redhead Viper, including one case of acute myocardial infarction (AMI). In recent years, our country with Jiangsu and Zhejiang (Bai Mei, Snake Island) viper, Agkistrodon acutus treatment of AMI, the effect is better. My School Institute of snake venom Guan Jinxia, Yu Qing Sheng Guangdong and other southern provinces contain a large number of cobra snake venom was found and found that this snake venom has good anticoagulant, fibrinolytic, platelet aggregation, the extract named “ Antithromboxin (ATX). ” After a series of basic experiments, we used to treat 17 cases of AMI, with satisfactory results. Eight patients initially treated with ATX I were reported in 1990 and this time along with nine patients treated with ATX II (anticoagulant, fibrinolytic and platelet-aggregating components) To sum up.