论文部分内容阅读
目的:探讨孕前期尿脂联素是否可以预测妊娠期糖尿病(GDM)的发生。方法:分别采用酶联免疫吸附法(ELISA)、葡萄糖氧化酶法、胰岛素采用化学发光自动分析方法测定126例GDM孕妇和血糖正常的134例孕妇。结果:孕l 6～2 l周时,GDM组尿脂联素低于对照组差异有统计学意义(P<0.05);血清胰岛素高于对照组差异有统计学意义(P<0.05)。GDM组、对照组尿脂联素与FBG无明显相关性(P>0.05),与胰岛素成负相关(r=﹣0.41,P<0.05;r=﹣0.56,P<0.05)。Logistic回归分析:尿脂联素与GDM的发病成负相关(r=0.34,P<0.05;β=0.128,P<0.05)。校正年龄、孕次、产次、BMI、胰岛素这些混淆因素后,尿脂联素水平仍与GDM的发生显著负相关(r=0.32,P<0.05;β=0.121,P<0.05)。结论:孕前期尿脂联素可预测妊娠期糖尿病的发生。
Objective: To investigate whether prenatal urinary adiponectin can predict gestational diabetes mellitus (GDM). Methods: Totally 126 pregnant women with GDM and 134 pregnant women with normal blood glucose were detected by chemiluminescence automatic analysis method using enzyme-linked immunosorbent assay (ELISA) and glucose oxidase method. Results: The level of urinary adiponectin in GDM group was significantly lower than that in control group (P <0.05) at 6 to 21 weeks of pregnancy, and the serum insulin level was significantly higher than that of control group (P <0.05). There was no significant correlation between adiponectin and FBG in GDM group and control group (P> 0.05), but negatively correlated with insulin (r = -0.41, P <0.05; r = -0.56, P <0.05). Logistic regression analysis showed that adiponectin was negatively correlated with the incidence of GDM (r = 0.34, P <0.05; β = 0.128, P <0.05). After adjusting for confounding factors such as age, gestational age, parity, BMI and insulin, the level of adiponectin was still negatively correlated with the occurrence of GDM (r = 0.32, P <0.05; β = 0.121, P <0.05). Conclusion: Pre-pregnancy urinary adiponectin can predict the occurrence of gestational diabetes mellitus.