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目的探讨促性腺激素释放激素激动剂(Gn RHa)及避孕药物预防女性卵巢生殖细胞肿瘤化疗患者卵巢损伤的临床疗效。方法收集女性生殖细胞肿瘤60例患者资料,将患者随机分为3组,各20例。对照组患者给予常规化疗,Gn RHa组患者在常规化疗的基础上肌内注射醋酸曲普瑞林,避孕药物组在化疗的基础上口服炔雌醇环丙孕酮片,在化疗过程中及停药后,定期监测患者的月经情况、排卵情况。结果对照组患者的排卵率、月经恢复率均明显低于Gn RHa组及避孕药物组,且对照组患者的卵巢功能早衰发生率明显高于Gn RHa组及避孕药物组;Gn RHa组患者的排卵率、月经恢复率均明显优于对照组和避孕药物组,且Gn RHa组患者的卵巢功能早衰发生率明显低于对照组和避孕药物组,差异均有统计学意义(均P<0.05)。结论 Gn RHa及避孕药物均可明显降低年轻女性卵巢生殖细胞肿瘤化疗所致卵巢功能损伤,保障患者预后及生活质量,但Gn RHa作用效果更优。
Objective To investigate the clinical efficacy of GnRa and contraceptives in the prevention of ovarian injury in women with ovarian germ cell tumor chemotherapy. Methods Sixty female patients with germ cell tumors were collected. The patients were randomly divided into three groups of 20 patients. The patients in the control group were given conventional chemotherapy. Patients in Gn RHa group received triptorelin acetate intramuscularly on the basis of conventional chemotherapy. The contraceptive drug group was given ethinyl estradiol cyproterone tablets on the basis of chemotherapy. During the course of chemotherapy, After medicine, regular monitoring of patients with menstrual conditions, ovulation conditions. Results The ovulation rate and the recovery rate of menstruation in the control group were significantly lower than those in the Gn RHa and contraceptive groups, and the incidence of premature ovarian failure in the control group was significantly higher than that in the Gn RHa and contraceptive groups. Ovulation Rate and menstruation recovery rate were significantly better than the control group and contraceptives group, and the incidence of premature ovarian failure in patients with Gn RHa group was significantly lower than the control group and contraceptives group, the difference was statistically significant (P <0.05). Conclusion Both Gn RHa and contraceptives can significantly reduce the ovarian function damage induced by ovarian germ cell tumor chemotherapy in young women and ensure the prognosis and quality of life of patients, but Gn RHa has better effect.